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Amazon EC2 now offers an automated connection set-up solution between EC2 instance and RDS Database

Starting today, in Amazon Elastic Compute Cloud (Amazon EC2), you have the option to automatically set up connectivity between the EC2 instances and an Amazon Relational Database Services (Amazon RDS) or Amazon Aurora database. Once you have provisioned EC2 instances, you can select a RDS db instance or cluster, and with a single click, complete connectivity configurations to allow traffic from the EC2 instance to the RDS database. Amazon EC2 follows the connectivity best practices and automatically sets up security groups on your behalf, helping to establish a secure connection.

Source:: Amazon AWS