Amazon AppStream 2.0 now supports the use of smart cards such as Personal Identity Verification (PIV) and Common Access Card (CAC) smart cards for authentication to AppStream 2.0 streaming instances. Smart cards are also supported for in-session authentication for streaming applications. With this launch, your users can use a smart card reader and smart card connected to their local computer to sign in to an AppStream 2.0 streaming instance that is joined to a Microsoft Active Directory domain. They can also use their local smart card reader and smart card to sign in to applications within their streaming session.
Source:: Amazon AWS