The Tuesday arrest of Giulio Occhionero and his sister, Francesca Maria, has brought to light what appears to be the biggest, and highest-profile, hacking of institutional and corporate accounts ever reported in Italy.

The siblings have been planting the Pyramid Eye remote access Trojan on computers using a spear-phishing technique over the course of years, according to the arrest order.

They attacked no fewer than 18,000 high-profile targets including former Prime Ministers Matteo Renzi and Mario Monti, President of European Central Bank Mario Draghi, as well as employees and heads of various ministries including Internal Affairs, Treasury, Finance, and Education.

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Siblings arrested in Italy’s worst cyberespionage operation ever